Article

PICK1 links KIBRA and AMPA receptors in coiled-coil-driven supramolecular complexes

2024-03-14

Abstract excerpt

The human memory-associated protein KIBRA regulates synaptic plasticity and trafficking of AMPA-type glutamate receptors, and is implicated in multiple neuropsychiatric and cognitive disorders. How KIBRA forms complexes with and regulates AMPA receptors remains unclear. Here, we show that KIBRA does not interact directly with the AMPA receptor subunit GluA2, but that PICK1, a key regulator of AMPA receptor traffic...

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Literature Corpus work: 0377dc07-c2c0-5e7c-8e50-f40d17ccc545
DOI: 10.1101/2024.03.12.584494

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