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Article

PICK1 mediates synaptic recruitment of AMPA receptors at neurexin-induced postsynaptic sites.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 12 Nov 2014

Xu Junyu, Kam Chuen, Luo Jian-Hong, Xia Jun

Abstract excerpt

In the CNS, synapse formation and maturation play crucial roles in the construction and consolidation of neuronal circuits. Neurexin and neuroligin localize on the opposite sides of synaptic membrane and interact with each other to promote the assembly and specialization of synapses. However, the excitatory synapses induced by the neurexin-neuroligin complex are initially immature synapses that lack AMPA...

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Source

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Identifiers

PMID: 25392508
DOI: 10.1523/JNEUROSCI.0296-14.2014
PMCID: PMC6608448

Genes

PICK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

PICK1 mediates synaptic recruitment of AMPA receptors at neurexin-induced postsynaptic sites.PMID 25392508Read ↗

Lipid binding regulates synaptic targeting of PICK1, AMPA receptor trafficking, and synaptic plasticity.Semantic proximity Read ↗

PICK1 mediates transient synaptic expression of GluA2-lacking AMPA receptors during glycine-induced AMPA receptor trafficking.Semantic proximity Read ↗

Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes.Semantic proximity Read ↗

NSF ATPase and alpha-/beta-SNAPs disassemble the AMPA receptor-PICK1 complex.Semantic proximity Read ↗

PICK1 expression in the Drosophila central nervous system primarily occurs in the neuroendocrine system.Semantic proximity Read ↗

The intellectual disability protein RAB39B selectively regulates GluA2 trafficking to determine synaptic AMPAR composition.Semantic proximity Read ↗

Calcium binding to PICK1 is essential for the intracellular retention of AMPA receptors underlying long-term depression.Semantic proximity Read ↗

NMDA receptor-mediated PIP5K activation to produce PI(4,5)P₂ is essential for AMPA receptor endocytosis during LTD.Semantic proximity Read ↗

PICK1 links AMPA receptor stimulation to Cdc42.Semantic proximity Read ↗

PICK1 links KIBRA and AMPA receptors in coiled-coil-driven supramolecular complexesSemantic proximity Read ↗

The PDZ domain of PICK1 differentially accepts protein kinase C-alpha and GluR2 as interacting ligands.Semantic proximity Read ↗

GluRδ2 assembles four neurexins into trans-synaptic triad to trigger synapse formation.Semantic proximity Read ↗

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