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Article

Interaction between the glutamate transporter GLT1b and the synaptic PDZ domain protein PICK1.

The European journal of neuroscience - 1 Jan 2008

Bassan Merav, Liu Hongguang, Madsen Kenneth L, Armsen Wencke, Zhou Jiayi, Desilva Tara, Chen Weizhi, Paradise Allison, Brasch Michael A, Staudinger Jeff, Gether Ulrik, Irwin Nina, Rosenberg Paul A

Abstract excerpt

Synaptic plasticity is implemented by the interaction of glutamate receptors with PDZ domain proteins. Glutamate transporters provide the only known mechanism of clearance of glutamate from excitatory synapses, and GLT1 is the major glutamate transporter. We show here that GLT1 interacts with the PDZ domain protein PICK1, which plays a critical role in regulating the expression of glutamate receptors at...

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Source

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Identifiers

PMID: 18184314
DOI: 10.1111/j.1460-9568.2007.05986.x
PMCID: PMC4341970

Genes

PICK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interaction between the glutamate transporter GLT1b and the synaptic PDZ domain protein PICK1.PMID 18184314Read ↗

The PDZ domain of PICK1 differentially accepts protein kinase C-alpha and GluR2 as interacting ligands.Semantic proximity Read ↗

Lipid binding regulates synaptic targeting of PICK1, AMPA receptor trafficking, and synaptic plasticity.Semantic proximity Read ↗

Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes.Semantic proximity Read ↗

Molecular determinants for PICK1 synaptic aggregation and mGluR7a receptor coclustering: role of the PDZ, coiled-coil, and acidic domains.Semantic proximity Read ↗

PICK1 expression in the Drosophila central nervous system primarily occurs in the neuroendocrine system.Semantic proximity Read ↗

Serine 77 in the PDZ domain of PICK1 is a protein kinase Cα phosphorylation site regulated by lipid membrane binding.Semantic proximity Read ↗

The binding affinities of proteins interacting with the PDZ domain of PICK1.Semantic proximity Read ↗

Calcium binding to PICK1 is essential for the intracellular retention of AMPA receptors underlying long-term depression.Semantic proximity Read ↗

Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel).Semantic proximity Read ↗

AMPA GluA2 subunit competitive inhibitors for PICK1 PDZ domain: Pharmacophore-based virtual screening, molecular docking, molecular dynamic simulation, and ADME studiesSemantic proximity Read ↗

PICK1 mediates synaptic recruitment of AMPA receptors at neurexin-induced postsynaptic sites.Semantic proximity Read ↗

Knock-in mice lacking the PDZ-ligand motif of mGluR7a show impaired PKC-dependent autoinhibition of glutamate release, spatial working memory deficits, and increased susceptibility to pentylenetetrazol.Semantic proximity Read ↗

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