Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phosphorylation and activation of Bub1 on unattached chromosomes facilitate the spindle checkpoint.

The EMBO journal - 4 Aug 2004

Chen Rey-Huei

Abstract excerpt

The spindle checkpoint inhibits anaphase until all kinetochores have attached properly to spindle microtubules. The protein kinase Bub1 is an essential checkpoint component that resides at kinetochores during mitosis. It is shown herein that Xenopus Bub1 becomes hyperphosphorylated and the kinase is activated on unattached chromosomes. MAP kinase (MAPK) contributes to this phosphorylation, as inhibiting MAPK or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle
Share to Cell Cycle Proteins
Share to Chromosomes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enzyme Activation

Share to Mutation

Share to Phosphorylation

Share to Protein Kinases

Share to Protein Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 15241477
DOI: 10.1038/sj.emboj.7600308
PMCID: PMC514925

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphorylation and activation of Bub1 on unattached chromosomes facilitate the spindle checkpoint.PMID 15241477Read ↗

Bub1p kinase activates the Saccharomyces cerevisiae spindle assembly checkpoint.Semantic proximity Read ↗

The Bub1-Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation.Semantic proximity Read ↗

Bub3p facilitates spindle checkpoint silencing in fission yeast.Semantic proximity Read ↗

CENP-E--dependent BubR1 autophosphorylation enhances chromosome alignment and the mitotic checkpoint.Semantic proximity Read ↗

Mutations in the essential spindle checkpoint gene bub1 cause chromosome missegregation and fail to block apoptosis in Drosophila.Semantic proximity Read ↗

Bimodal activation of BubR1 by Bub3 sustains mitotic checkpoint signaling.Semantic proximity Read ↗

Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage.Semantic proximity Read ↗

The Bub2-dependent mitotic pathway in yeast acts every cell cycle and regulates cytokinesis.Semantic proximity Read ↗

Bub1 regulates chromosome segregation in a kinetochore-independent manner.Semantic proximity Read ↗

Signaling protein abundance modulates the strength of the Spindle Assembly CheckpointSemantic proximity Read ↗

The BUBR1 pseudokinase domain promotes efficient kinetochore PP2A-B56 recruitment to regulate spindle checkpoint silencing and chromosome alignmentSemantic proximity Read ↗

Impaired Bub1 function in vivo compromises tension-dependent checkpoint function leading to aneuploidy and tumorigenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.