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Article

Phosphorylation and activation of Bub1 on unattached chromosomes facilitate the spindle checkpoint.

The EMBO journal - 4 Aug 2004

Chen Rey-Huei

Abstract excerpt

The spindle checkpoint inhibits anaphase until all kinetochores have attached properly to spindle microtubules. The protein kinase Bub1 is an essential checkpoint component that resides at kinetochores during mitosis. It is shown herein that Xenopus Bub1 becomes hyperphosphorylated and the kinase is activated on unattached chromosomes. MAP kinase (MAPK) contributes to this phosphorylation, as inhibiting MAPK or...

Topics

Animals
Cell Cycle
Cell Cycle Proteins
Chromosomes
Enzyme Activation
Extracellular Signal-Regulated MAP Kinases
Kinetochores
Mutation
Ovum
Phosphorylation
Protein Kinases
Protein Serine-Threonine Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Spindle Apparatus

Xenopus laevis

Source

Open in PubMed Open full text

Identifiers

PMID: 15241477
DOI: 10.1038/sj.emboj.7600308
PMCID: PMC514925

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-15241477-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Phosphorylation and activation of Bub1 on unattached chromosomes facilitate the spindle checkpoint.PMID 15241477Read ↗

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