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Article

The Bub2-dependent mitotic pathway in yeast acts every cell cycle and regulates cytokinesis.

Journal of cell science - 1 Jun 2001

Lee S E, Jensen S, Frenz L M, Johnson A L, Fesquet D, Johnston L H

Abstract excerpt

In eukaryotes an abnormal spindle activates a conserved checkpoint consisting of the MAD and BUB genes that results in mitotic arrest at metaphase. Recently, we and others identified a novel Bub2-dependent branch to this checkpoint that blocks mitotic exit. This cell-cycle arrest depends upon inhibition of the G-protein Tem1 that appears to be regulated by Bfa1/Bub2, a two-component GTPase-activating protein, and...

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Identifiers

PMID: 11493673
DOI: 10.1242/jcs.114.12.2345

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Bub2-dependent mitotic pathway in yeast acts every cell cycle and regulates cytokinesis.PMID 11493673Read ↗

Different levels of Bfa1/Bub2 GAP activity are required to prevent mitotic exit of budding yeast depending on the type of perturbations.Semantic proximity Read ↗

The Bfa1/Bub2 GAP complex comprises a universal checkpoint required to prevent mitotic exit.Semantic proximity Read ↗

The C-terminus of Bfa1p in budding yeast is essential to induce mitotic arrest in response to diverse checkpoint-activating signals.Semantic proximity Read ↗

Bfa1 can regulate Tem1 function independently of Bub2 in the mitotic exit network of Saccharomyces cerevisiae.Semantic proximity Read ↗

Disappearance of the budding yeast Bub2-Bfa1 complex from the mother-bound spindle pole contributes to mitotic exit.Semantic proximity Read ↗

The V260I mutation in fission yeast alpha-tubulin Atb2 affects microtubule dynamics and EB1-Mal3 localization and activates the Bub1 branch of the spindle checkpoint.Semantic proximity Read ↗

Cdc5-dependent asymmetric localization of bfa1 fine-tunes timely mitotic exit.Semantic proximity Read ↗

BUB1 and BUBR1: multifaceted kinases of the cell cycle.Semantic proximity Read ↗

Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage.Semantic proximity Read ↗

Spatial regulation of the spindle assembly checkpoint and anaphase-promoting complex in Aspergillus nidulans.Semantic proximity Read ↗

Uncoupling of the spindle-checkpoint and chromosome-congression functions of BubR1.Semantic proximity Read ↗

Temporal coupling of spindle disassembly and cytokinesis is disrupted by deletion of LTE1 in budding yeast.Semantic proximity Read ↗

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