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Article

Proteins with simplified hydrophobic cores compared to other packing mutants.

Biophysical chemistry - 1 Aug 2004

Chen Junmei, Lu Zhiqiang, Sakon Joshua, Stites Wesley E

Abstract excerpt

Efforts to design proteins with greatly reduced sequence diversity have often resulted in proteins with so-called molten globule properties. Substitutions were made at six neighboring sites in the major hydrophobic core of staphylococcal nuclease to create variants with all leucine, all isoleucine or all valine at these sites. The mutant proteins with simplified cores constructed here are quite unstable and have...

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Identifiers

PMID: 15228960
DOI: 10.1016/j.bpc.2004.02.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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