Article
Hydrophobic core malleability of a de novo designed three-helix bundle protein.
Journal of molecular biology - 12 Jan 2001
Walsh S T, Sukharev V I, Betz S F, Vekshin N L, DeGrado W F
Abstract excerpt
De novo protein design provides a tool for testing the principles that stabilize the structures of proteins. Recently, we described the design and structure determination of alpha(3)D, a three-helix bundle protein with a well-packed hydrophobic core. Here, we test the malleability and adaptability of this protein's structure by mutating a small, Ala residue (A60) in its core to larger, hydrophobic side-chains,...
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