Core-packing constraints, hydrophobicity and protein design.

doi:10.1016/0958-1669(94)90048-5

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Article

Core-packing constraints, hydrophobicity and protein design.

Current opinion in biotechnology - 1 Aug 1994

Baldwin E P, Matthews B W

Abstract excerpt

Recent crystallographic studies have shown that both backbone and side-chain adjustments occur when different core-packing arrangements are accommodated in proteins. Thus, modeling methods, which have typically considered only side-chain adjustments, must now also account for backbone movements t...

Topics

Genetic Variation
Mathematical Computing
Models, Chemical
Mutagenesis
Protein Conformation
Protein Engineering

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