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Article

Core-packing constraints, hydrophobicity and protein design.

Current opinion in biotechnology - 1 Aug 1994

Baldwin E P, Matthews B W

Abstract excerpt

Recent crystallographic studies have shown that both backbone and side-chain adjustments occur when different core-packing arrangements are accommodated in proteins. Thus, modeling methods, which have typically considered only side-chain adjustments, must now also account for backbone movements to accurately predict the energies and structures of mutated or designed proteins. The 'plasticity' of protein cores...

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PMID: 7765172
DOI: 10.1016/0958-1669(94)90048-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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