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Article

What makes a protein a protein? Hydrophobic core designs that specify stability and structural properties.

Protein science : a publication of the Protein Society - 1 Aug 1996

Munson M, Balasubramanian S, Fleming K G, Nagi A D, O'Brien R, Sturtevant J M, Regan L

Abstract excerpt

Here we describe how the systematic redesign of a protein's hydrophobic core alters its structure and stability. We have repacked the hydrophobic core of the four-helix-bundle protein, Rop, with altered packing patterns and various side chain shapes and sizes. Several designs reproduce the struct...

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Identifiers

PMID: 8844848
DOI: 10.1002/pro.5560050813
PMCID: PMC2143493

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-8844848-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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