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Article

Mobile unnatural amino acid side chains in the core of staphylococcal nuclease.

Protein science : a publication of the Protein Society - 1 Jun 1996

Wynn R, Harkins P C, Richards F M, Fox R O

Abstract excerpt

The structures of several variants of staphylococcal nuclease with long flexible unnatural amino acid side chains in the hydrophobic core have been determined by X-ray crystallography. The unnatural amino acids are disulfide moieties between the lone cysteine residue in V23C nuclease and methane, ethane, 1-n-propane, 1-n-butane, 1-n-pentane, and 2-hydroxyethyl thiols. We have examined changes in the core packing...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 8762134
DOI: 10.1002/pro.5560050605
PMCID: PMC2143447

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Source receipt: pubmed, retrieved 7 Sept 2026.

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