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Article

Active barnase variants with completely random hydrophobic cores.

Proceedings of the National Academy of Sciences of the United States of America - 28 May 1996

Axe D D, Foster N W, Fersht A R

Abstract excerpt

The central structural feature of natural proteins is a tightly packed and highly ordered hydrophobic core. If some measure of exquisite, native-like core packing is necessary for enzymatic function, this would constitute a significant obstacle to the development of novel enzymes, either by design or by natural or experimental evolution. To test the minimum requirements for a core to provide sufficient structural...

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Identifiers

PMID: 8643620
DOI: 10.1073/pnas.93.11.5590
PMCID: PMC39291

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Source receipt: pubmed, retrieved 7 Sept 2026.

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