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Article

Aggregated polyglutamine peptides delivered to nuclei are toxic to mammalian cells

22 Oct 2002

Abstract excerpt

A number of observations point to the aggregation of expanded polyglutamine [poly(Q)]-containing proteins as playing a central role in the etiology of Huntington's disease (HD) and other expanded CAG-repeat diseases. Transfected cell and transgenic animal models provide some of this support, but irrefutable data on the cytotoxicity of poly(Q) aggregates is lacking. This may be due in part to difficulties in...

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PMID: 12393802
DOI: 10.1093/hmg/11.23.2905

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