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Article

Soluble Oligomers of PolyQ-Expanded Huntingtin Target a Multiplicity of Key Cellular Factors.

Molecular cell - 15 Sept 2016

Kim Yujin E, Hosp Fabian, Frottin Frédéric, Ge Hui, Mann Matthias, Hayer-Hartl Manajit, Hartl F Ulrich

Abstract excerpt

Huntington's disease is one of several neurodegenerative disorders characterized by the aggregation of polyglutamine (polyQ)-expanded mutant protein. How polyQ aggregation leads to cellular dysfunction is not well understood. Here, we analyzed aberrant protein interactions of soluble oligomers and insoluble inclusions of mutant huntingtin using in-cell single molecule fluorescence spectroscopy and quantitative...

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Identifiers

PMID: 27570076
DOI: 10.1016/j.molcel.2016.07.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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