Article
Folding Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No Detectable Monomer.
PloS one - 1 Jan 2016
Sahoo Bankanidhi, Arduini Irene, Drombosky Kenneth W, Kodali Ravindra, Sanders Laurie H, Greenamyre J Timothy, Wetzel Ronald
Abstract excerpt
Expansion of the polyglutamine (polyQ) track of the Huntingtin (HTT) protein above 36 is associated with a sharply enhanced risk of Huntington's disease (HD). Although there is general agreement that HTT toxicity resides primarily in N-terminal fragments such as the HTT exon1 protein, there is no consensus on the nature of the physical states of HTT exon1 that are induced by polyQ expansion, nor on which of these...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.