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Article

Heat shock promotes inclusion body formation of mutant huntingtin (mHtt) and alleviates mHtt-induced transcription factor dysfunction.

The Journal of biological chemistry - 5 Oct 2018

Chen Justin Y, Parekh Miloni, Seliman Hadear, Bakshinskaya Dariya, Dai Wei, Kwan Kelvin, Chen Kuang Yu, Liu Alice Y C

Abstract excerpt

PolyQ-expanded huntingtin (mHtt) variants form aggregates, termed inclusion bodies (IBs), in individuals with and models of Huntington's disease (HD). The role of IB versus diffusible mHtt in neurotoxicity remains unclear. Using a ponasterone (PA)-inducible cell model of HD, here we evaluated the effects of heat shock on the appearance and functional outcome of Htt103QExon1-EGFP expression. Quantitative image...

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Identifiers

PMID: 30143534
DOI: 10.1074/jbc.RA118.002933
PMCID: PMC6177601

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