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Article

Formation and toxicity of soluble polyglutamine oligomers in living cells.

PloS one - 28 Dec 2010

Lajoie Patrick, Snapp Erik Lee

Abstract excerpt

BACKGROUND: Aggregation and cytotoxicity of mutant proteins containing an expanded number of polyglutamine (polyQ) repeats is a hallmark of several diseases, including Huntington's disease (HD). Within cells, mutant Huntingtin (mHtt) and other polyglutamine expansion mutant proteins exist as mono...

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Identifiers

PMID: 21209946
DOI: 10.1371/journal.pone.0015245
PMCID: PMC3011017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21209946-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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