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Article

Spontaneous self-assembly of pathogenic huntingtin exon 1 protein into amyloid structures.

Essays in biochemistry - 1 Jan 2014

Trepte Philipp, Strempel Nadine, Wanker Erich E

Abstract excerpt

PolyQ (polyglutamine) diseases such as HD (Huntington's disease) or SCA1 (spinocerebellar ataxia type 1) are neurodegenerative disorders caused by abnormally elongated polyQ tracts in human proteins. PolyQ expansions promote misfolding and aggregation of disease-causing proteins, leading to the appearance of nuclear and cytoplasmic inclusion bodies in patient neurons. Several lines of experimental evidence...

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Source

Identifiers

PMID: 25131594
DOI: 10.1042/bse0560167

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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