Neurotoxic protein oligomerisation associated with polyglutamine diseases.

Abstract excerpt

Polyglutamine (polyQ) diseases are associated with a CAG/polyQ expansion mutation in unrelated proteins. Upon elongation of the glutamine tract, disease proteins aggregate within cells, mainly in the central nervous system (CNS) and this aggregation process is associated with neurotoxicity. However, it remains unclear to what extent and how this aggregation causes neuronal dysfunction in the CNS. Aiming at...

Topics

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• Central Nervous System Diseases
• Models, Biological
• Mutation
• Nerve Tissue Proteins
• Peptides
• Protein Binding