Article
The folate pathway is a target for resistance to the drug para-aminosalicylic acid (PAS) in mycobacteria.
Molecular microbiology - 1 Jul 2004
Rengarajan Jyothi, Sassetti Christopher M, Naroditskaya Vera, Sloutsky Alexander, Bloom Barry R, Rubin Eric J
Abstract excerpt
The increasing rate of multidrug-resistant tuberculosis has led to more use of second-line antibiotics such as para-aminosalicylic acid (PAS). The mode of action of PAS remains unclear, and mechanisms of resistance to this drug are undefined. We have isolated PAS-resistant transposon mutants of Mycobacterium bovis BCG with insertions in the thymidylate synthase (thyA) gene, a critical determinant of intracellular...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.