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Article

para-Aminosalicylic acid is a prodrug targeting dihydrofolate reductase in Mycobacterium tuberculosis.

The Journal of biological chemistry - 9 Aug 2013

Zheng Jun, Rubin Eric J, Bifani Pablo, Mathys Vanessa, Lim Vivian, Au Melvin, Jang Jichan, Nam Jiyoun, Dick Thomas, Walker John R, Pethe Kevin, Camacho Luis R

Abstract excerpt

para-Aminosalicylic acid (PAS) is one of the antimycobacterial drugs currently used for multidrug-resistant tuberculosis. Although it has been in clinical use for over 60 years, its mechanism(s) of action remains elusive. Here we report that PAS is a prodrug targeting dihydrofolate reductase (DHFR) through an unusual and novel mechanism of action. We provide evidences that PAS is incorporated into the folate...

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Share to Antitubercular Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dihydropteroate Synthase

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Source

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Identifiers

PMID: 23779105
DOI: 10.1074/jbc.M113.475798
PMCID: PMC5395024

Genes

DHFR
DHPS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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