Article
Genes required for intrinsic multidrug resistance in Mycobacterium avium.
Antimicrobial agents and chemotherapy - 1 Sept 2004
Philalay Julie S, Palermo Christine O, Hauge Kirsten A, Rustad Tige R, Cangelosi Gerard A
Abstract excerpt
Genes required for intrinsic multidrug resistance by Mycobacterium avium were identified by screening a library of transposon insertion mutants for the inability to grow in the presence of ciprofloxacin, clarithromycin, and penicillin at subinhibitory concentrations. Two genes, pks12 and Maa2520, were disrupted in multiple drug-susceptible mutants. The pks12 gene (Maa1979), which may be cotranscribed with a...
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