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Article

A vitamin B₁₂ transporter in Mycobacterium tuberculosis.

Open biology - 13 Feb 2013

Gopinath Krishnamoorthy, Venclovas Ceslovas, Ioerger Thomas R, Sacchettini James C, McKinney John D, Mizrahi Valerie, Warner Digby F

Abstract excerpt

Vitamin B₁₂-dependent enzymes function in core biochemical pathways in Mycobacterium tuberculosis, an obligate pathogen whose metabolism in vivo is poorly understood. Although M. tuberculosis can access vitamin B₁₂ in vitro, it is uncertain whether the organism is able to scavenge B₁₂ during host infection. This question is crucial to predictions of metabolic function, but its resolution is complicated by the...

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Identifiers

PMID: 23407640
DOI: 10.1098/rsob.120175
PMCID: PMC3603451

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