Targeting DNA Replication and Repair for the Development of Novel Therapeutics against Tuberculosis

Abstract excerpt

Mycobacterium tuberculosis is the etiological agent of tuberculosis (TB), an infectious disease which results in approximately 10 million incident cases and 1.4 million deaths globally each year, making it the leading cause of mortality from infection. An effective frontline combination chemotherapy exists for TB; however, this regimen requires the administration of four drugs in a two month intensive phase...

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