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Article

Binding pocket alterations in dihydrofolate synthase confer resistance to para-aminosalicylic acid in clinical isolates of Mycobacterium tuberculosis.

Antimicrobial agents and chemotherapy - 1 Jan 2014

Zhao Fei, Wang Xu-De, Erber Luke N, Luo Ming, Guo Ai-zhen, Yang Shan-shan, Gu Jing, Turman Breanna J, Gao Yun-rong, Li Dong-fang, Cui Zong-qiang, Zhang Zhi-ping, Bi Li-jun, Baughn Anthony D, Zhang Xian-En, Deng Jiao-Yu

Abstract excerpt

The mechanistic basis for the resistance of Mycobacterium tuberculosis to para-aminosalicylic acid (PAS), an important agent in the treatment of multidrug-resistant tuberculosis, has yet to be fully defined. As a substrate analog of the folate precursor para-aminobenzoic acid, PAS is ultimately bioactivated to hydroxy dihydrofolate, which inhibits dihydrofolate reductase and disrupts the operation of...

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Identifiers

PMID: 24366731
DOI: 10.1128/AAC.01775-13
PMCID: PMC3957869

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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