Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations in dnaA and a cryptic interaction site increase drug resistance in Mycobacterium tuberculosis.

PLoS pathogens - 1 Nov 2020

Hicks Nathan D, Giffen Samantha R, Culviner Peter H, Chao Michael C, Dulberger Charles L, Liu Qingyun, Stanley Sydney, Brown Jessica, Sixsmith Jaimie, Wolf Ian D, Fortune Sarah M

Abstract excerpt

Genomic dissection of antibiotic resistance in bacterial pathogens has largely focused on genetic changes conferring growth above a single critical concentration of drug. However, reduced susceptibility to antibiotics-even below this breakpoint-is associated with poor treatment outcomes in the clinic, including in tuberculosis. Clinical strains of Mycobacterium tuberculosis exhibit extensive quantitative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antitubercular Agents
Share to Bacterial Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

Share to DNA Replication

Share to Drug Resistance, Multiple, Bacterial

Share to Isoniazid

Share to Mycobacterium tuberculosis

Share to Tuberculosis

Source

Open in PubMed Open full text

Identifiers

PMID: 33253310
DOI: 10.1371/journal.ppat.1009063
PMCID: PMC7738170

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations in dnaA and a cryptic interaction site increase drug resistance in Mycobacterium tuberculosis.PMID 33253310Read ↗

Intracellular Drug Targets In Mycobacterium Tuberculosis Revealed By A Chemo-Genetic ApproachSemantic proximity Read ↗

Mycobacterium tuberculosis functional genetic diversity, altered drug sensitivity, and precision medicine.Semantic proximity Read ↗

Encoded metabolic remodeling amplifies drug resistance in <i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

Deciphering Bedaquiline and Clofazimine Resistance in Tuberculosis: An Evolutionary Medicine ApproachSemantic proximity Read ↗

Encoded metabolic remodeling amplifies drug resistance in Mycobacterium tuberculosis.Semantic proximity Read ↗

CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosisSemantic proximity Read ↗

TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities.Semantic proximity Read ↗

Whole genome CRISPRi screening identifies druggable vulnerabilities in an isoniazid resistant strain of Mycobacterium tuberculosis.Semantic proximity Read ↗

Genome wide analyses reveal the role of mutator phenotypes in the emergence of drug resistance in <i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

Intragenic Distribution of IS6110 in Clinical Mycobacterium tuberculosis Strains: Bioinformatic Evidence for Gene Disruption Leading to Underdiagnosed Antibiotic Resistance.Semantic proximity Read ↗

Genome wide analyses reveal the role of mutator phenotypes in Mycobacterium tuberculosis drug resistance emergenceSemantic proximity Read ↗

Genetic mechanisms of co-emergence of INH-resistant Mycobacterium tuberculosis strains during the standard course of antituberculosis therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.