Article
Structure-function relationship of the extracellular calcium-sensing receptor.
Cell calcium - 1 Mar 2004
Bai Mei
Abstract excerpt
The extracellular calcium-sensing receptor (CaR) originally cloned from bovine parathyroid gland is a G protein-coupled receptor. The physiological relevance of the cloned CaR for sensing and regulating the extracellular calcium concentration has been established by identifying hyper- and hypocalcemic disorders resulting from inactivating and activating mutations, respectively, in the CaR. The cloned CaR has been...
Topics
- Allosteric Regulation
- Amino Acid Sequence
- Amino Acids
- Animals
- Calcium
- Cystine
- Dimerization
- Extracellular Space
- Glycosylation
- Humans
- Models, Biological
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Protein Conformation
- Protein Kinase C
- Protein Structure, Quaternary
- Receptors, Calcium-Sensing
