Article
Cloning and functional characterization of extracellular Ca(2+)-sensing receptors from parathyroid and kidney.
Bone - 1 Aug 1995
Brown E M, Pollak M, Chou Y H, Seidman C E, Seidman J G, Hebert S C
Abstract excerpt
Parathyroid cells recognize and respond to (i.e., "sense") minute perturbations in the extracellular ionized calcium concentration (Ca2+o), but the mechanisms underlying this process have remained obscure. Recently, we employed expression cloning in Xenopus laevis oocytes to isolate a cDNA coding for a Ca2+o-sensing receptor from bovine parathyroid. Like the native receptor, the cloned Ca2+o-sensing receptor...
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