Article
Cloning and functional characterization of extracellular Ca(2+)-sensing receptors from parathyroid and kidney.
Bone - 1 Aug 1995
Brown E M, Pollak M, Chou Y H, Seidman C E, Seidman J G, Hebert S C
Abstract excerpt
Parathyroid cells recognize and respond to (i.e., "sense") minute perturbations in the extracellular ionized calcium concentration (Ca2+o), but the mechanisms underlying this process have remained obscure. Recently, we employed expression cloning in Xenopus laevis oocytes to isolate a cDNA coding...
Topics
- Amino Acid Sequence
- Animals
- Calcium-Binding Proteins
- Cattle
- Cloning, Molecular
- DNA, Complementary
- Humans
- Hypercalcemia
- Hyperparathyroidism
- Infant, Newborn
- Kidney
- Molecular Sequence Data
- Mutation
- Parathyroid Glands
- Receptors, Calcium-Sensing
- Receptors, Cell Surface
- Second Messenger Systems