Molecular biology and clinical importance of the Ca(2+)-sensing receptor.

doi:10.1097/00008480-199808000-00019

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Article

Molecular biology and clinical importance of the Ca(2+)-sensing receptor.

Current opinion in pediatrics - 1 Aug 1998

De Luca F, Baron J

Abstract excerpt

The Ca(2+)-sensing receptor (CaR) is a member of the seven-transmembrane domain, G protein-coupled receptor super-family. In the parathyroid gland, it mediates the inhibitory effects of extracellular Ca2+ on the secretion of parathyroid hormone. In the kidney, activation of the CaR causes decreas...

Topics

Calcium
Homeostasis
Humans
Hypercalcemia
Hyperparathyroidism
Kidney
Molecular Biology
Mutation
Parathyroid Glands
Receptors, Calcium-Sensing
Receptors, Cell Surface

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