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Article

Structure and function of the human calcium-sensing receptor: insights from natural and engineered mutations and allosteric modulators.

Journal of cellular and molecular medicine - 1 Jan 2000

Hu Jianxin, Spiegel Allen M

Abstract excerpt

The human extracellular Ca(2+)-sensing receptor (CaR), a member of the G protein-coupled receptor family 3, plays a key role in the regulation of extracellular calcium homeostasis. It is one of just a few G protein-coupled receptors with a large number of naturally occurring mutations identified in patients. In contrast to the small sizes of its agonists, this large dimeric receptor consists of domains with...

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Identifiers

PMID: 17979873
DOI: 10.1111/j.1582-4934.2007.00096.x
PMCID: PMC4401263

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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