Article
Role of calcium-sensing receptor in mineral ion metabolism and inherited disorders of calcium-sensing.
Molecular genetics and metabolism - 1 Nov 2006
Chattopadhyay Naibedya, Brown Edward M
Abstract excerpt
The extracellular calcium-sensing receptor (CaR), a G protein-coupled receptor that resides on the parathyroid cell surface negatively regulates secretion of parathyroid hormone (PTH). The CaR is functionally expressed in bone, kidney, and gut--the three major calcium-translocating organs involved in calcium homeostasis. Further studies are needed to define fully the homeostatic roles of the CaR in tissues that...
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