Article
Differential effects of Rho GTPases on axonal and dendritic development in hippocampal neurones.
Journal of neurochemistry - 1 Jul 2004
Ahnert-Hilger G, Höltje M, Grosse G, Pickert G, Mucke C, Nixdorf-Bergweiler B, Boquet P, Hofmann F, Just I
Abstract excerpt
Formation of neurites and their differentiation into axons and dendrites requires precisely controlled changes in the cytoskeleton. While small GTPases of the Rho family appear to be involved in this regulation, it is still unclear how Rho function affects axonal and dendritic growth during development. Using hippocampal neurones at defined states of differentiation, we have dissected the function of RhoA in...
Topics
- ADP Ribose Transferases
- Adenosine Diphosphate Ribose
- Animals
- Axons
- Botulinum Toxins
- Cells, Cultured
- Dendrites
- Gene Transfer Techniques
- Genes, Dominant
- Hippocampus
- Isoenzymes
- Mice
- Mice, Inbred Strains
- Neurons