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Article

Inhibition of Rho-dependent pathways by Clostridium botulinum C3 protein induces a proinflammatory profile in microglia.

Glia - 15 Aug 2008

Hoffmann Anja, Hofmann Fred, Just Ingo, Lehnardt Seija, Hanisch Uwe-Karsten, Brück Wolfgang, Kettenmann Helmut, Ahnert-Hilger Gudrun, Höltje Markus

Abstract excerpt

Successful regeneration in the central nervous system crucially depends on the adequate environment. Microglia as brain immune-competent cells importantly contribute to this task by producing pro- and anti-inflammatory mediators. Any environmental change transforms these cells towards an activated phenotype, leading to major morphological, transcriptional and functional alterations. Rho GTPases affect multiple...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 18442097
DOI: 10.1002/glia.20687

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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