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Article

Proteome Alterations of Hippocampal Cells Caused by Clostridium botulinum C3 Exoenzyme.

Journal of proteome research - 6 Nov 2015

Schröder Anke, Rohrbeck Astrid, Just Ingo, Pich Andreas

Abstract excerpt

C3bot from Clostridium botulinum is a bacterial mono-ADP-ribosylating enzyme, which transfers an ADP-ribose moiety onto the small GTPases Rho A/B/C. C3bot and the catalytic inactive mutant (C3E174Q) cause axonal and dendritic growth as well as branching in primary hippocampal neurons. In cultured murine hippocampal HT22 cells, protein abundances were analyzed in response to C3bot or C3E174Q treatment using a...

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PMID: 26393427
DOI: 10.1021/acs.jproteome.5b00591

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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