Article
C3 exoenzyme lacks effects on peripheral axon regeneration in vivo.
Journal of the peripheral nervous system : JPNS - 1 Mar 2013
Auer Maria, Allodi Ilary, Barham Mohammed, Udina Esther, Neiss Wolfram F, Navarro Xavier, Klimaschewski Lars
Abstract excerpt
Peripheral nerve injury triggers the activation of the small GTPase RhoA in spinal motor and peripheral sensory neurons. C3 transferase, an exoenzyme produced by Clostridium botulinum that inactivates RhoA by ADP-ribosylation, has been successfully applied in central nervous system (CNS) lesion models to facilitate regeneration functionally and morphologically. Until now it has not been demonstrated if C3bot...
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