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Article

Inhibition of Rho is required for cAMP-induced melanoma cell differentiation.

Molecular biology of the cell - 1 Jun 1998

Buscà R, Bertolotto C, Abbe P, Englaro W, Ishizaki T, Narumiya S, Boquet P, Ortonne J P, Ballotti R

Abstract excerpt

Up-regulation of the cAMP pathway by forskolin or alpha-melanocyte stimulating hormone induces melanocyte and melanoma cell differentiation characterized by stimulation of melanin synthesis and dendrite development. Here we show that forskolin-induced dendricity is associated to a disassembly of actin stress fibers. Since Rho controls actin organization, we studied the role of this guanosine triphosphate...

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Identifiers

PMID: 9614180
DOI: 10.1091/mbc.9.6.1367
PMCID: PMC25356

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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