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Article

Diverse roles of Rho family GTPases in neuronal development, survival, and death

1 Nov 2007

Abstract excerpt

Rho family GTPases (eg., RhoA, Rac1 and Cdc42) are monomeric G-proteins that act as key transducers of extracellular signals to the actin cytoskeleton. In the nervous system, Rho family GTPases are essential regulators of neuronal growth cone motility, axonal migration, and dendritic spine morphogenesis. Given these vital functions, it is perhaps not surprising that mutations in several proteins involved in Rho...

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PMID: 17981578
DOI: 10.2741/2710

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