Article
Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E.
Proceedings of the National Academy of Sciences of the United States of America - 20 Jul 2004
Michelsen Kathrin S, Wong Michelle H, Shah Prediman K, Zhang Wenxuan, Yano Juliana, Doherty Terence M, Akira Shizuo, Rajavashisth Tripathi B, Arditi Moshe
Abstract excerpt
Toll-like receptors (TLRs) and the downstream adaptor molecule myeloid differentiation factor 88 (MyD88) play an essential role in the innate immune responses. Here, we demonstrate that genetic deficiency of TLR4 or MyD88 is associated with a significant reduction of aortic plaque areas in atherosclerosis-prone apolipoprotein E-deficient mice, despite persistent hypercholesterolemia, implying an important role...
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