Article
Evidence for a role of macrophage migration inhibitory factor in vascular disease.
Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2004
Chen Zhiping, Sakuma Masashi, Zago Alexandre C, Zhang Xiaobin, Shi Can, Leng Lin, Mizue Yuka, Bucala Richard, Simon Daniel
Abstract excerpt
OBJECTIVE: Inflammation plays an essential role in atherosclerosis and restenosis. Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that is widely expressed in vascular cells. However, there is no in vivo evidence that MIF participates directly in vascular injury and repair. Therefore, we investigated the effect of MIF blockade on the response to experimental angioplasty in...
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