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Article

Influence of interferon-gamma on the extent and phenotype of diet-induced atherosclerosis in the LDLR-deficient mouse.

Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2003

Buono Chiara, Come Carolyn E, Stavrakis George, Maguire Graham F, Connelly Philip W, Lichtman Andrew H

Abstract excerpt

OBJECTIVE: The aim of this study was to investigate the influence of interferon-gamma (IFN-gamma) on atherosclerosis in low density lipoprotein receptor (LDLR)-null mice. METHODS AND RESULTS: We cross-bred IFN-gamma-deficient mice with LDLR-null mice and analyzed lipoprotein profiles and atherosclerosis in the compound mutant progeny after 8 and 20 weeks on a cholesterol-enriched diet. IFN-gamma deficiency did...

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Source

Identifiers

PMID: 12615659
DOI: 10.1161/01.ATV.0000059419.11002.6E

Genes

LDLR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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