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Article

Phosphorylated eukaryotic translation initiation factor 4 (eIF4E) is elevated in human cancer tissues

1 Aug 2009

Abstract excerpt

Eukaryotic translation initiation factor 4E (eIF4E) is a rate-limiting factor for cap-dependent protein synthesis and is regulated by PI3 kinase/mTOR and mitogen-activated protein kinase (MAPK)/Mnk signaling pathways. Recent studies have shown that Mnk-mediated eIF4E phosphorylation is absolutely required for eIF4E's oncogenic function. Overexpression of eIF4E has been reported in many types of cancers; however,...

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PMID: 19483468
DOI: 10.4161/cbt.8.15.8960

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