Article

Computational inference of eIF4F complex function and structure in human cancers

2023-08-11

Abstract excerpt

The canonical eukaryotic initiation factor 4F (eIF4F) complex, composed of eIF4G1, eIF4A1, and the cap-binding protein eIF4E, plays a crucial role in cap-dependent translation initiation in eukaryotic cells (1). However, cap-independent initiation can occur through internal ribosomal entry sites (IRESs), involving only eIF4G1 and eIF4A1 present, which is considered to be a complementary process to cap-dependent in...

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Literature Corpus work: 5bd0f989-30d7-50c8-b911-ee0b71f39dde
DOI: 10.1101/2023.08.10.552450

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