Article

Deep computational analysis of human cancer and non-cancer tissues details dysregulation of eIF4F components and their interactions in human cancers

2020-10-12

Abstract excerpt

<h4>SUMMARY</h4> Eukaryotic translation initiation complex (eIF4F) plays roles so diverse in human cancers as to complicate development of an overarching understanding of eIF4F’s functional and regulatory impacts across tumor types. Our analysis of large public data sets yielded several useful findings. EIF4G1 frequently gains gene copies and is overexpressed to achieve characteristic stoichiometries with EIF4E...

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Literature Corpus work: bfdc2550-1857-5335-8d41-a4803f6d2ffe
DOI: 10.1101/2020.10.12.336263

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