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Article

4E-BP1, a multifactor regulated multifunctional protein

22 Feb 2016

Abstract excerpt

Eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1) is a member of a family of translation repressor proteins, and a well-known substrate of mechanistic target of rapamycin (mTOR) signaling pathway. Phosphorylation of 4E-BP1 causes its release from eIF4E to allow cap-dependent translation to proceed. Recently, 4E-BP1 was shown to be phosphorylated by other kinases besides mTOR, and...

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PMID: 26901143
DOI: 10.1080/15384101.2016.1151581

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