Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Eukaryotic initiation factor 4E variants alter the morphology, proliferation, and colony-formation properties of MDA-MB-435 cancer cells.

Molecular carcinogenesis - 1 Jan 2007

Goldson Tovë M, Vielhauer George, Staub Eveline, Miller Steve, Shim Hyunsuk, Hagedorn Curt H

Abstract excerpt

Eukaryotic initiation factor 4E (eIF4E) binds to the 5' m(7)G cap of mRNAs and is a focal point of regulation of initiation of mRNA translation. High levels of expression of eIF4E in many epithelial cancers, including breast, head and neck, colon, and bladder, correlate with increased tissue inva...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5' Untranslated Regions
Share to Eukaryotic Initiation Factor-4E
Share to Peptide Chain Initiation, Translational

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polyribosomes

Share to RNA Caps

Share to Staurosporine

Share to Tumor Stem Cell Assay

Share to Vascular Endothelial Growth Factor A

Source

Identifiers

PMID: 17091471
DOI: 10.1002/mc.20276

Genes

GAPDH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17091471-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Eukaryotic initiation factor 4E variants alter the morphology, proliferation, and colony-formation properties of MDA-MB-435 cancer cells.PMID 17091471Read ↗

Targeting the eIF4F translation initiation complex for cancer therapySemantic proximity Read ↗

Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells.Semantic proximity Read ↗

Targeting the Eukaryotic Translation Initiation Factor 4E for Cancer TherapySemantic proximity Read ↗

The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth.Semantic proximity Read ↗

CELF1 is an EIF4E binding protein that promotes translation of epithelial-mesenchymal transition effector mRNAsSemantic proximity Read ↗

Deep computational analysis of human cancer and non-cancer tissues details dysregulation of eIF4F components and their interactions in human cancersSemantic proximity Read ↗

eIF3d and eIF3e mediate selective translational control of hypoxia that can be inhibited by novel small moleculesSemantic proximity Read ↗

Computational inference of eIF4F complex function and structure in human cancersSemantic proximity Read ↗

The Translation Initiation Factor eIF-4E Binds to a Common Motif Shared by the Translation Factor eIF-4γ and the Translational Repressors 4E-Binding ProteinsSemantic proximity Read ↗

Robust eIF4B levels undermine invasive growth and immune evasion mechanisms in murine triple negative breast cancer modelsSemantic proximity Read ↗

Phosphorylated eukaryotic translation initiation factor 4 (eIF4E) is elevated in human cancer tissuesSemantic proximity Read ↗

Loss-of-function cancer-associated mutations in the EIF4G2 non-canonical translation initiation factorSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.