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Article

The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth.

Oncogene - 5 Dec 1996

Rousseau D, Gingras A C, Pause A, Sonenberg N

Abstract excerpt

Initiation in eukaryotes is the rate limiting step of translation. The binding of the mRNA to the 40S ribosomal subunit, which is mediated by the mRNA cap structure, is a key target for control of protein synthesis. The cap binding protein, eIF4E, is the most limiting of all initiation factors and its overexpression in NIH3T3 cells causes malignant transformation. 4E-binding protein 1 (BP1) and 4E-BP2 are small...

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PMID: 8957083

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth.PMID 8957083Read ↗

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