Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The homozygous FcgammaRIIIa-158V genotype is a risk factor for heparin-induced thrombocytopenia in patients with antibodies to heparin-platelet factor 4 complexes.

Blood - 1 Nov 2004

Gruel Yves, Pouplard Claire, Lasne Dominique, Magdelaine-Beuzelin Charlotte, Charroing Chloé, Watier Hervé

Abstract excerpt

We hypothesized that Fcgamma receptor IIIa (FcgammaRIIIa), a polymorphic receptor for the Fc portion of immunoglobulin G (IgG) other than FcgammaRIIa, was involved in heparin-induced thrombocytopenia (HIT). FcgammaRIIa-131 and FcgammaRIIIa-158 genotypes were determined in 102 patients with definite HIT and in 2 control groups of patients treated by heparin (86 subjects without detectable antibodies [Abs] to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD
Share to Autoantibodies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Case-Control Studies

Share to Gene Frequency

Share to Heparin

Share to Homozygote

Share to Receptors, IgG

Share to Thrombocytopenia

Source

Identifiers

PMID: 15191947
DOI: 10.1182/blood-2004-01-0058

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The homozygous FcgammaRIIIa-158V genotype is a risk factor for heparin-induced thrombocytopenia in patients with antibodies to heparin-platelet factor 4 complexes.PMID 15191947Read ↗

Heparin-induced thrombocytopenia: new insights into the impact of the FcgammaRIIa-R-H131 polymorphism.Semantic proximity Read ↗

Heparin-induced thrombocytopenia: the role of platelets genetic polymorphisms.Semantic proximity Read ↗

Increased risk of thrombosis in FcγRIIA 131RR patients with HIT due to defective control of platelet activation by plasma IgG2.Semantic proximity Read ↗

Importance of the FcgammaRIIa-Arg/His-131 polymorphism in heparin-induced thrombocytopenia diagnosis.Semantic proximity Read ↗

Single amino acid mutation of Fc gamma receptor is associated with the development of heparin-induced thrombocytopenia.Semantic proximity Read ↗

On the role of platelet Fc gamma RIIa phenotype in heparin-induced thrombocytopenia.Semantic proximity Read ↗

Polymorphism of the Fcγ Receptor II as a Possible Predisposing Factor for Heparin-Induced Thrombocytopenia.Semantic proximity Read ↗

[Polymorphisms of FcγRIIA, FcγRIIIA and FcγRIIB in patients with immune thrombocytopenia and their clinical significance].Semantic proximity Read ↗

FC gamma receptor polymorphisms in patients with immune thrombocytopenia.Semantic proximity Read ↗

Involvement of Fc gamma receptor polymorphism in the therapeutic response of idiopathic thrombocytopenic purpura.Semantic proximity Read ↗

The impact of Fc gamma receptor IIa and IIIa gene polymorphisms on the therapeutic response of rituximab in Egyptian adult immune thrombocytopenic purpura.Semantic proximity Read ↗

The platelet Fc receptor, FcγRIIa.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.