Heparin-induced thrombocytopenia: new insights into the impact of the FcgammaRIIa-R-H131 polymorphism.

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Article

Heparin-induced thrombocytopenia: new insights into the impact of the FcgammaRIIa-R-H131 polymorphism.

Blood - 1 Sept 1998

Carlsson L E, Santoso S, Baurichter G, Kroll H, Papenberg S, Eichler P, Westerdaal N A, Kiefel V, van de Winkel J G, Greinacher A

Abstract excerpt

Heparin-induced thrombocytopenia (HIT), a severe complication of heparin treatment, can be associated with new thrombotic complications. HIT antibodies activate platelets via the platelet Fcgamma-receptor (FcgammaRIIa), which carries a functionally relevant polymorphism (FcgammaRIIa-R-H131). The...

Topics

Antigens, CD
Genotype
Heparin
Humans
Platelet Activation
Polymerase Chain Reaction
Polymorphism, Genetic
Prospective Studies
Receptors, IgG
Risk Factors
Thrombocytopenia
Thrombosis

Source

Open in PubMed

Identifiers

PMID: 9716579

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9716579-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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