Article
Polymorphism of the Fcγ Receptor II as a Possible Predisposing Factor for Heparin-Induced Thrombocytopenia.
Clinical laboratory - 1 Jan 2015
Slavik Ludek, Svobodova Gabriela, Ulehlova Jana, Krcova Vera, Hlusi Antonin, Prochazkova Jana, Hutyra Martin
Abstract excerpt
BACKGROUND: Heparin-induced thrombocytopenia (HIT) represents a serious complication of heparin treatment. IgG antibodies binding platelet factor 4 (PF4) and heparin trigger the clinical manifestations of HIT. However, only a portion of the antibodies have the ability to activate platelets, and these can be identified by a platelet aggregation test (functional testing). However, this expression has been detected...
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