Article
On the role of platelet Fc gamma RIIa phenotype in heparin-induced thrombocytopenia.
Thrombosis and haemostasis - 1 Dec 1995
Brandt J T, Isenhart C E, Osborne J M, Ahmed A, Anderson C L
Abstract excerpt
Heparin induced thrombocytopenia (HIT) is characterized by the formation of antibodies that activate normal donor platelets in vitro in the presence of heparin. We asked whether the commonly observed donor-specific variation in the platelet aggregation response to HIT antibodies is influenced by the density of Fc gamma RII on platelets or by the Arg/His 131 allelic polymorphism of platelet Fc gamma RII. We found...
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