Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased risk of thrombosis in FcγRIIA 131RR patients with HIT due to defective control of platelet activation by plasma IgG2.

Blood - 9 Apr 2015

Rollin Jérôme, Pouplard Claire, Sung Hsueh Cheng, Leroux Dorothée, Saada Armand, Gouilleux-Gruart Valérie, Thibault Gilles, Gruel Yves

Abstract excerpt

Thrombosis results in heparin-induced thrombocytopenia (HIT) from cellular activation involving Fc receptors. In this study, the FcγRIIA 131RR genotype was found to increase the risk of thrombosis in HIT patients (odds ratio: 5.9; 95% confidence interval: 1.7-20). When platelet aggregation tests...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anticoagulants
Share to Heparin
Share to Immunoglobulin G

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Platelet Activation

Share to Polymorphism, Genetic

Share to Receptors, IgG

Share to Thrombocytopenia

Share to Thrombosis

Source

Identifiers

PMID: 25680756
DOI: 10.1182/blood-2014-09-594515

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25680756-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased risk of thrombosis in FcγRIIA 131RR patients with HIT due to defective control of platelet activation by plasma IgG2.PMID 25680756Read ↗

Importance of the FcgammaRIIa-Arg/His-131 polymorphism in heparin-induced thrombocytopenia diagnosis.Semantic proximity Read ↗

Heparin-induced thrombocytopenia: new insights into the impact of the FcgammaRIIa-R-H131 polymorphism.Semantic proximity Read ↗

The homozygous FcgammaRIIIa-158V genotype is a risk factor for heparin-induced thrombocytopenia in patients with antibodies to heparin-platelet factor 4 complexes.Semantic proximity Read ↗

On the role of platelet Fc gamma RIIa phenotype in heparin-induced thrombocytopenia.Semantic proximity Read ↗

Polymorphism of the Fcγ Receptor II as a Possible Predisposing Factor for Heparin-Induced Thrombocytopenia.Semantic proximity Read ↗

Heparin-induced thrombocytopenia: the role of platelets genetic polymorphisms.Semantic proximity Read ↗

Single amino acid mutation of Fc gamma receptor is associated with the development of heparin-induced thrombocytopenia.Semantic proximity Read ↗

The platelet Fc receptor, FcγRIIa.Semantic proximity Read ↗

Anti-miR-148a regulates platelet FcγRIIA signaling and decreases thrombosis in vivo in mice.Semantic proximity Read ↗

Platelet FcgammaRIIA His131Arg polymorphism and platelet function: antibodies to platelet-bound fibrinogen induce platelet activation.Semantic proximity Read ↗

Novel Strategy to Combat the Procoagulant Phenotype in Heparin-Induced Thrombocytopenia Using 12-LOX Inhibition.Semantic proximity Read ↗

Polymorphisms of protein tyrosine phosphatase CD148 influence FcγRIIA-dependent platelet activation and the risk of heparin-induced thrombocytopenia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.